Research Explorer

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Project

The role of innate-like T cells in combined gut-joint disease in spondyloarthritis

Outputs and Outcomes

Publications

Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells

Tan-Yun ChengT PraveenaSrinath GovindarajanCatarina F AlmeidaDaniel G PellicciWellington C ArkinsIldiko Van RhijnKoen VenkenDirk ElewautDale I GodfreyJamie RossjohnD Branch Moody et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis

Koen VenkenTine DecruyTim SparwasserDirk Elewaut

A1 Journal Article in IMMUNOLOGY

Sterile triggers drive joint inflammation in TNF‐ and IL-1β‐dependent mouse arthritis models

Alexandra ThiranIoanna PettaGillian BlanckeMarie ThorpGuillaume PlanckaertMaude JansVanessa AndriesKorneel BarbryElisabeth GilisJulie CoudenysTino HochepiedChristian VanhoveEric GraceyEmilie DumasTeddy ManuelloIván JosipovicGeert van LooDirk ElewautLars Vereecke et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Joke DeprezRein VerbekeSofie MeulewaeterIlke AernoutHeleen DewitteTine DecruyJulie CoudenysJulie Van DuyseGert Van IsterdaelDan PeerRoy van der MeelStefaan De SmedtPeggy JacquesDirk ElewautIne Lentacker et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

Gut inflammation in axial spondyloarthritis patients is characterized by a marked type 17 skewed mucosal innate‐like T cell signature

Céline MortierKatrien QuintelierAnn-Sophie De CraemerThomas RensonLiselotte DerooEmilie DumasEveline VerheugenJulie CoudenysTine DecruyZuzanna ŁukasikSofie Van GassenYvan SaeysAnne HoorensTriana Lobatón OrtegaFilip Van den BoschTom Van de WieleKoen VenkenDirk Elewaut et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis

Koen VenkenMatthias JarlborgTine DecruyCéline MortierCarolien VliegheElisabeth GilisAnn-Sophie De CraemerJulie CoudenysIsabelle CambréDevan FleuryAlexander KlimowiczFilip Van den BoschAnne HoorensTriana Lobatón OrtegaSytze de RoockTim SparwasserGerald NaboznyPeggy JacquesDirk Elewaut et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

ROR gamma t inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating gamma delta-T cells

Céline MortierEric GraceyJulie CoudenysTeddy ManuelloTine DecruyMargaux MaelegheerFlore StappersElisabeth GilisDjoere GaublommeLuc Van HoorebekeSophie Van WeldenCatherine AmblerMartin HegenPeter SymanowiczStefan SteynGabriel BersteinDirk ElewautKoen Venken et al.

A1 Journal Article in RHEUMATOLOGY

In vitro triple coculture with gut microbiota from spondyloarthritis patients is characterized by inter-individual differences in inflammatory responses

Annelore BeteramsMarta Calatayud ArroyoKim De PaepeAnn-Sophie De CraemerDirk ElewautKoen VenkenTom Van de Wiele

A1 Journal Article in SCIENTIFIC REPORTS

Effect of impaired T cell receptor signaling on the gut microbiota in a mouse model of systemic autoimmunity

Mirei ShirakashiMikako MaruyaKeiji HirotaTatsuaki TsuruyamaTakashi MatsuoRyu WatanabeKoichi MurataMasao TanakaHiromu ItoHajime YoshifujiKoichiro OhmuraDirk ElewautShimon SakaguchiSidonia FagarasanTsuneyo MimoriMotomu Hashimoto et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Crossing the boundaries : IL-23 and its role in linking inflammation of the skin, gut and joints

Zuzanna ŁukasikEric GraceyKoen VenkenChristopher RitchlinDirk Elewaut

A1 Journal Article in RHEUMATOLOGY

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

Eric GraceyArne BurssensIsabelle CambréGeorg SchettRik LoriesIain B McInnesHiroshi AsaharaDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops

Isabelle CambréDjoere GaublommeNadia SchryversStijn LambrechtRik LoriesKoen VenkenDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen VenkenPeggy JacquesCéline MortierMark E. LabadiaTine DecruyJulie CoudenysKathleen HoytAnita L. WayneRobert HughesMichael TurnerSofie Van GassenLiesbet MartensDustin SmithChristian HarckenJoseph WahleChao-Ting WangEveline VerheugenNadia SchryversGaëlle VarkasHeleen CypersRuth WittoekYves PietteLieve GyselbrechtSerge Van CalenberghFilip Van den BoschYvan SaeysGerald NaboznyDirk Elewaut et al.

A1 Journal Article in NATURE COMMUNICATIONS