Code
01D25319
Duration
01 October 2019 → 31 October 2020
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Natural sciences
- Genetics not elsewhere classified
-
Medical and health sciences
- Cardiac and vascular medicine not elsewhere classified
- Medical biochemistry and metabolism not elsewhere classified
Keywords
Medial vascular calcification
pseudoxanthoma elasticum
natural history
Inorganic pyrophosphate
lipid metabolism
Project description
In this PhD project, a heritable form of medial vascular calcification (VCm) will be studied namely pseudoxanthoma elasticum (PXE), caused by ABCC6 mutations. The natural history of VCm in PXE patients, causative molecular mechanisms and the role of dysfunctional lipid metabolism will be studied, contributing to improved clinical management and prognosis of patients with VCm phenotypes.