Research Explorer

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Project

High pressure intraperitoneal aerosolization of chemotherapeutics, nanoparticles and hydrogels to treat peritoneal carcinomatosis: effect on tumor penetration, biodistribution and anti-cancer activity.

Outputs & Impact

Publications & research data ( 12 )

The effect of electrostatic high pressure nebulization on the stability, activity and ex vivo distribution of ionic self-assembled nanomedicines

Helena BraetValentina AndrettoRemco MariënBeyza YücesanStefan van der VegteRagna HaegebaertGiovanna LolloStefaan De SmedtKatrien Remaut

A1 Journal Article in ACTA BIOMATERIALIA

Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions

Helena BraetPeter-Paul FransenYong ChenSimon Van HerckRemco MariënValérie VanhoorneWim CeelenAnnemieke MadderSteven BalletRichard Hoogenboom et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis

Helena BraetPeter-Paul FransenRemco MariënGiovanna LolloWim CeelenChris VervaetLieve BalcaenFrank VanhaeckeChristian VanhoveStefan van der Vegte et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Nanoparticle mediated targeting of toll-like receptors to treat colorectal cancer

Ragna HaegebaertMaxime KempersWim CeelenIne LentackerKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery

Helena BraetMohammad Rahimi GorjiCharlotte DebbautG GhorbaniaslThibault Van WalleghemSenne CornelisSarah CosynsChris VervaetWouter WillaertWim Ceelen et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Intraperitoneal aerosolized drug delivery : technology, recent developments, and future outlook

Mohammad Rahimi GorjiLeen Van de SandeCharlotte DebbautGhader GhorbaniaslHelena BraetSarah CosynsKatrien RemautWouter WillaertWim Ceelen

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine : cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate peritoneal metastasis of advanced human ovarian cancer

Molood ShariatiGiovanna LolloKevin MathaBenedicte DescampsChristian VanhoveLeen Van de SandeWouter WillaertLieve BalcaenFrank VanhaeckeJean-Pierre Benoit et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation

Leen Van de SandeMohammad Rahimi GorjiSilvia GiordanoEnrico DavoliCristina MatteoSonke DetlefsenKatharina D'HerdeHelena BraetMolood ShariatiKatrien Remaut et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Intraperitoneal chemotherapy for peritoneal metastases : an expert opinion

Wim CeelenHelena BraetGabrielle Van RamshorstWouter WillaertKatrien Remaut

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

Aerosolization of nanotherapeutics as a newly emerging treatment regimen for peritoneal carcinomatosis

Molood ShariatiWouter WillaertWim CeelenStefaan De SmedtKatrien Remaut

A1 Journal Article in CANCERS

High pressure nebulization (PIPAC) versus injection for the intraperitoneal administration of mRNA complexes

Molood ShariatiHeyang ZhangLeen Van de SandeBenedicte DescampsChristian VanhoveWouter WillaertWim CeelenStefaan De SmedtKatrien Remaut

A1 Journal Article in PHARMACEUTICAL RESEARCH

Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Leen Van de SandeWouter WillaertSarah CosynsKaat De ClercqMolood ShariatiKatrien RemautWim Ceelen

A1 Journal Article in BMC CANCER

Activities ( 0 )

Results

Impact narratives ( 2 )

Cancer: peritoneum

Cancer: treatment

Area(s): Health

Patents ( 0 )