Project

High pressure intraperitoneal aerosolization of chemotherapeutics, nanoparticles and hydrogels to treat peritoneal carcinomatosis: effect on tumor penetration, biodistribution and anti-cancer activity.

Publications

The effect of electrostatic high pressure nebulization on the stability, activity and ex vivo distribution of ionic self-assembled nanomedicines

Helena BraetValentina AndrettoRemco MariënBeyza YücesanStefan van der VegteRagna HaegebaertGiovanna LolloStefaan De SmedtKatrien Remaut

A1 Journal Article in ACTA BIOMATERIALIA

2023

Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions

Helena BraetPeter-Paul FransenYong ChenSimon Van HerckRemco MariënValérie VanhoorneWim CeelenAnnemieke MadderSteven BalletRichard HoogenboomBruno De GeestAnne HoorensPatricia Y.W. DankersStefaan De SmedtKatrien Remaut et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2023

CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis

Helena BraetPeter-Paul FransenRemco MariënGiovanna LolloWim CeelenChris VervaetLieve BalcaenFrank VanhaeckeChristian VanhoveStefan van der VegteElke GasthuysAn VermeulenPatricia Y.W. DankersStefaan De SmedtKatrien Remaut et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

2023

Nanoparticle mediated targeting of toll-like receptors to treat colorectal cancer

Ragna HaegebaertMaxime KempersWim CeelenIne LentackerKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2022

Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery

Helena BraetMohammad Rahimi GorjiCharlotte DebbautG GhorbaniaslThibault Van WalleghemSenne CornelisSarah CosynsChris VervaetWouter WillaertWim CeelenStefaan De SmedtKatrien Remaut et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2021

Intraperitoneal aerosolized drug delivery : technology, recent developments, and future outlook

Mohammad Rahimi GorjiLeen Van de SandeCharlotte DebbautGhader GhorbaniaslHelena BraetSarah CosynsKatrien RemautWouter WillaertWim Ceelen

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

2020

Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine : cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate peritoneal metastasis of advanced human ovarian cancer

Molood ShariatiGiovanna LolloKevin MathaBenedicte DescampsChristian VanhoveLeen Van de SandeWouter WillaertLieve BalcaenFrank VanhaeckeJean-Pierre BenoitWim CeelenStefaan De SmedtKatrien Remaut et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

2020

Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation

Leen Van de SandeMohammad Rahimi GorjiSilvia GiordanoEnrico DavoliCristina MatteoSonke DetlefsenKatharina D'HerdeHelena BraetMolood ShariatiKatrien RemautFei XieCharlotte DebbautGhader GhorbaniaslSarah CosynsWouter WillaertWim Ceelen et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

2020

Intraperitoneal chemotherapy for peritoneal metastases : an expert opinion

Wim CeelenHelena BraetGabrielle Van RamshorstWouter WillaertKatrien Remaut

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

2020

Aerosolization of nanotherapeutics as a newly emerging treatment regimen for peritoneal carcinomatosis

Molood ShariatiWouter WillaertWim CeelenStefaan De SmedtKatrien Remaut

A1 Journal Article in CANCERS

2019

High pressure nebulization (PIPAC) versus injection for the intraperitoneal administration of mRNA complexes

Molood ShariatiHeyang ZhangLeen Van de SandeBenedicte DescampsChristian VanhoveWouter WillaertWim CeelenStefaan De SmedtKatrien Remaut

A1 Journal Article in PHARMACEUTICAL RESEARCH

2019

Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Leen Van de SandeWouter WillaertSarah CosynsKaat De ClercqMolood ShariatiKatrien RemautWim Ceelen

A1 Journal Article in BMC CANCER

2019