A discovery and engineering platform for lysins as a novel class of antibiotics

01 October 2019 → 31 October 2020
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Infectious diseases
    • Metagenomics
  • Medical and health sciences
    • Drug discovery and development not elsewhere classified
Antibiotics functional metagenomics microfluidics protein engineering
Project description

Lysins are novel enzyme-based antibiotics with proven clinical potential. This project proposes a performant discovery and engineering platform for lysins using functional metagenomics, microfluidics and advanced protein engineering. This platform aims to fuel the (pre)clinical pipeline of lysins for new therapies against a diversity of pathogens and to establish lysins as a broad class of novel antibiotics.