Research Explorer

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Project

Smart design nanoParticles to Activate immune Responses against Cancer (SPARC)

Outputs and Outcomes

Publications

Preclinical toxicological assessment of an alpha-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs

Sofie MeulewaeterMargo De VelderDiethard ReckelbusKevin MwangiThomas EhouarneIlke AernoutYanou EngelenFëllanza HalimiIsis Van herteryckLobke De BelsValerie RedantLouise De la ManeJoline IngelsBo CoppensSerge Van CalenberghPieter CornillieGabriële HoltappelsBenedicte DescampsDaisy VanrompayStefaan De SmedtWim Van Den BroeckBart VandekerckhoveMathias DevreeseRein VerbekeIne Lentacker et al.

A2 Journal Article in MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT

The role of mRNA-galsomes and LNPs in enhancing HIV-specific T cell responses across various lymphoid organs

Sigrid D’haeseSabine den RooverRein VerbekeIlke AernoutSofie MeulewaterJoëlle CosynsJessy MeertSarah VanbellingenThessa LaeremansIne LentackerJoeri L. Aerts et al.

A1 Journal Article in MOLECULAR THERAPY NUCLEIC ACIDS

Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria

Sofie MeulewaeterIlke AernoutJoke DeprezYanou EngelenMargo De VelderLorenzo FranceschiniKarine BreckpotSerge Van CalenberghCaroline AsselmanKatie BoucherFrancis ImpensStefaan De SmedtRein VerbekeIne Lentacker et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Sustained release of a human PD-L1 single-domain antibody using peptide-based hydrogels

Julie HeremansRobin Maximilian AwadJessica BridouxThomas ErtveldtVicky CaveliersAnnemieke MadderRichard HoogenboomNick DevoogdtSteven BalletSophie HernotKarine BreckpotCharlotte Martin et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

Sofie MeulewaeterGust NuyttenMiffy H.Y. ChengStefaan De SmedtPieter R. CullisThomas De BeerIne LentackerRein Verbeke

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Nanoparticle mediated targeting of toll-like receptors to treat colorectal cancer

Ragna HaegebaertMaxime KempersWim CeelenIne LentackerKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across

An-Katrien MinnaertHelena VanlucheneRein VerbekeIne LentackerStefaan De SmedtKoen RaemdonckNiek SandersKatrien Remaut

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS