Research Explorer

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Project

Exploration of an mRNA based nanovaccine platform and immunopeptidomics for the development of more effective tuberculosis vaccines.

Outputs & Impact

Publications & research data ( 9 )

Sequence simplification of antigen coding IVT mRNA allows accelerated synthetic DNA template generation and epitope immunogenicity validation

Arthur EspritDorien AutaersIlke AernoutIne LentackerSteve PascoloKris ThielemansKarine BreckpotLorenzo Franceschini

A1 Journal Article in MOLECULAR THERAPY NUCLEIC ACIDS

Challenges and opportunities in mRNA vaccine development against bacteria

Ilke AernoutRein VerbekeFabien Henri TheryPatrick WillemsUri EliaStefaan De SmedtRino RappuoliDan PeerFrancis ImpensIne Lentacker

A1 Journal Article in NATURE MICROBIOLOGY

Preclinical toxicological assessment of an α-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs

Sofie MeulewaeterMargo De VelderDiethard ReckelbusKevin MwangiThomas EhouarneIlke AernoutYanou EngelenFëllanza HalimiIsis Van herteryckLobke De Bels et al.

A1 Journal Article in MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT

Current state of mRNA vaccine development against Mycobacterium tuberculosis

Ilke AernoutRein VerbekeStefaan De SmedtFrancis ImpensIne Lentacker

Bookchapter in Trends in mRNA vaccine research

Photoporation of NK-92MI cells with biodegradable polydopamine nanosensitizers as a promising strategy for the generation of engineered NK cell therapies

Charlotte HinnekensAranit HarizajDominika BerdeckaIlke AernoutMolood ShariatiStefanie PeetersEva LionStefaan De SmedtBart VandekerckhoveKevin Braeckmans et al.

A1 Journal Article in APPLIED MATERIALS TODAY

The role of mRNA-galsomes and LNPs in enhancing HIV-specific T cell responses across various lymphoid organs

Sigrid D’haeseSabine den RooverRein VerbekeIlke AernoutSofie MeulewaterJoëlle CosynsJessy MeertSarah VanbellingenThessa LaeremansIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY NUCLEIC ACIDS

Immunopeptidomics mapping of Listeria monocytogenes T cell epitopes in mice

Adillah GulLecia L. PewePatrick WillemsRupert MayerFabien Henri TheryCaroline AsselmanIlke AernoutRein VerbekeDenzel EggermontLaura Van Moortel et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria

Sofie MeulewaeterIlke AernoutJoke DeprezYanou EngelenMargo De VelderLorenzo FranceschiniKarine BreckpotSerge Van CalenberghCaroline AsselmanKatie Boucher et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Joke DeprezRein VerbekeSofie MeulewaeterIlke AernoutHeleen DewitteTine DecruyJulie CoudenysJulie Van DuyseGert Van IsterdaelDan Peer et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )