Project

The metastic niche: preparation, function and translational evidence of a permissieve micro environment for cancer dissemination

Acronym
De metastische niche-1
Duration
01 January 2013 → 31 October 2019
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Medical and health sciences
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
  • Engineering and technology
    • Catalysis and reacting systems engineering
    • Chemical product design and formulation
    • General chemical and biochemical engineering
    • Process engineering
    • Separation and membrane technologies
    • Transport phenomena
    • Other (bio)chemical engineering
Keywords
Premetastatic niche cancer exosome
 
Project description

Establishment of cancer metastases is “successful” only if premetastatic niches are prepared in certain organs. Exosomes derived from cancer cells, are presumed to contribute to this process. In this project the biogenesis of exosomes is studied, and transgenic animals will be applied. Last but not least, exosome markers will be traced in organs (lymph nodes, bone marrow, lung) from cancer patients, as predictive markers.