Project

Study of the influence of (recently identified) regulators on necroptosis (oxidative) metabolism

Duration
01 January 2012 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Atomic and molecular physics
    • Biochemistry and metabolism
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
Metabolisme mitochondria cell death
 
Project description

Necroptosis is a regulated form of cell death, and of special importance during inflammatory responses. From a previous screen, we identified novel regulators of necroptosis. After validation, a search for the molecular mechanism starts (i.e. ffects on initiation, propagation, execution, or rather a preconditioning mechanism). The crosslink between metabolism and regulated cell death is unclear and will be further investigated.