Project

Role of biomechanical stress in inflammatory arthritis

Code
3G051016
Duration
01 January 2016 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Orthopaedics
    • Orthopaedics
    • Orthopaedics
Keywords
innate immunity biomechanical stress arthritis
 
Project description

Our team previously showed in a mousemodel of spondyloarthritis, that biomechanical stress may be a critical factor in onset of disease, partly explaining the peculiar localization of this systemic disease. This proposal will explore the underlying mechanisms by which mechanical strain leads to joint inflammation, using both valuable patient samples and validated mouse-models.