Project

Combined single-channel electrophysiology and fluorescence microscopy for fundamental studies of ion channel function

Duration
01 June 2018 → 31 May 2020
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Medicinal and biomolecular chemistry
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Molecular and cell biology
    • Physiology
    • Biophysics
    • Molecular and cell biology
    • Physiology
    • Biophysics
    • Molecular and cell biology
    • Physiology
Keywords
microscopy laser scanning electrophysiology patch-clamp ion channels
 
Project description

Patch-clamp electrophysiology allows detailed investigations of ion channel function at the level of conformational changes in individual proteins in real-time. Combined with laser-scanning microscopy and fluorescent indicators, the technique allows to monitor additional signals that are involved in ion channel regulation. Overall, the approach is an essential tool for obtaining insight into the physiology/pharmacology of ion channels and receptor-coupled channels.