Project

Molecular mechanisms of the lifespan-doubling effect of axenic culture in the nematode caenorhabditis elegans.

Duration
01 March 2013 → 30 September 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
    • General biology
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
C. elegans transcriptomics ageing physiology
 
Project description

Axenically cultured C. Elegans lives twice as long compared to worms in bacterial culture. A list of genes will be tested for their role in this lifespan extension. In parallel, we will perform transcriptomics to gereate extra candidate genes. Genes that are shown to be required for axenic lifespan extension will be further characterzed by expression studies and Rnai.