Project

Molecular mechanisms of the lifespan-doubling effect of axenic culture in the nematode caenorhabditis elegans.

Code

01SC0313

Duration

01 March 2013 → 30 September 2016

Funding

Regional and community funding: Special Research Fund

Promotor

Bart Braeckman

Fellow

Huaihan Cai

Research disciplines

Natural sciences
- Animal biology
- Biochemistry and metabolism
- General biology
- Systems biology
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
Agricultural and food sciences
- Veterinary medicine

Keywords

C. elegans transcriptomics ageing physiology

Project description

Axenically cultured C. Elegans lives twice as long compared to worms in bacterial culture. A list of genes will be tested for their role in this lifespan extension. In parallel, we will perform transcriptomics to gereate extra candidate genes. Genes that are shown to be required for axenic lifespan extension will be further characterzed by expression studies and Rnai.