Research Explorer

Project

Metabolic engineering for the creation of a platform organism with an increased nucleotide sugar pool
Code
178BW0111
Duration
01 October 2010 → 05 January 2016
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Engineering and technology
    • Biocatalysis and enzyme technology
    • Bioprocessing, bioproduction and bioproducts
    • Fermentation
    • Industrial microbiology
    • Industrial molecular engineering of nucleic acids and proteins
    • Industrial biotechnology not elsewhere classified
Keywords
UDP-sugars metabolic engineering ecsherichia oligosaccharides
 
Project description

The goal of this research is to create a platform organism with an increased intracellular pool of UDP-sugars. The developed technology is based on the principles of metabolic engineering of the model organism Escherichia coli. The created mutants will function as glycosylation platforms for the production of various oligosaccharides and glycoconjugates.