Role of connexin channels in the transfer of apoptotic signals

01 October 2007 → 30 September 2012
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Systems biology
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Neurosciences
    • Physiology
    • Neurosciences
    • Physiology
    • Neurosciences
    • Physiology
gap junctions apoptosis hemichannels
Project description

Gap junctions allow the passage of molecules less than 1,5 kDa between neighbouring cells. They are important in the expansion of apoptotic cell death, in which hemichannels, 'half of a gap junction channel', also could contribute via paracrine signaling. The goal is to investigate the role of both channels in apoptosis as well as to identify the modulating apoptotic signals.