Project

Investigating the role of intestinal epithelial TRAF6 signalling in intestinal and extra-intestinal Th17-driven immune responses

Duration
01 October 2016 → 25 May 2017
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Immunology
    • Neurosciences
    • Gastro-enterology and hepatology
    • Immunology
    • Neurosciences
    • Gastro-enterology and hepatology
    • Immunology
    • Neurosciences
Keywords
gut-brain axis TRAF6 Multiple Sclerosis
 
Project description

IL-17A-producing T helper (Th17) cells, which contribute to Multiple Sclerosis (MS), are educated by an immunological gut-brain axis, in which we suspect a role for intestinal epithelial TRAF6 signalling. Therefore, we will investigate the role of intestinal TRAF6 signalling in a mouse model of MS. Understanding such gut-derived immune effects on the brain might aid in designing novel MS therapies.