Research Explorer

Project

Model-based design of spin freezing process using detailed Computational Fluid Dynamics (CFD) simulation
Code
01CD18324
Duration
01 February 2025 → 31 May 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Pharmaceutical technology
  • Engineering and technology
    • Modelling, simulation and optimisation
    • Chemical process design
    • Powder and particle technology
Keywords
Simulation Computational fluid dynamics (CFD) Modeling Lyophilization
 
Project description
 The spin-freezing process, part of a novel freeze-drying method, involves vial rotation along its longitudinal axis while a nozzle directs cooling gas to freeze the liquid. Using Computational Fluid Dynamics (CFD), we analyze nozzle configurations to optimize cooling performance and meet GMP requirements, ensuring an efficient and compliant process design.