Code
01D29117
Duration
01 January 2018 → 31 December 2021
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Immunology
- Molecular and cell biology
- Morphological sciences
- Oncology
- Immunology
- Morphological sciences
- Oncology
- Immunology
- Molecular and cell biology
- Morphological sciences
- Oncology
Keywords
non-small cell lung carcinoma
immunotherapy
immunomonitoring
dendritic cell vaccinations
neoantigen specific T-cells
innate PD-1+CD8αα+ T-cells
Project description
In this project we will study the induction of neoantigen specific T cell responses by neoantigen loaded dendritic cell vaccinations in patients with non-small cell lung carcinoma and correlate these responses with clinical course. In addition, the presence of a recently described innate, PD1+CD8αα+ T-cell population will be studied in tumor lesions.