Project

Immunomonitoring of patients with non-small cell lung carcinoma treated with a tumor mutanome-targeted dendritic cell vaccine

Duration
01 January 2018 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
Keywords
non-small cell lung carcinoma immunotherapy immunomonitoring dendritic cell vaccinations neoantigen specific T-cells innate PD-1+CD8αα+ T-cells
 
Project description

In this project we will study the induction of neoantigen specific T cell responses by neoantigen loaded dendritic cell vaccinations in patients with non-small cell lung carcinoma and correlate these responses with clinical course. In addition, the presence of a recently described innate, PD1+CD8αα+ T-cell population will be studied in tumor lesions.