Unraveling the mechanisms that drive cardiovascular manifestations in Marfan syndrome using mouse models

01 November 2023 → 30 April 2024
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal pathology
    • Physiology
    • Genomics
    • Proteomics
    • Transcriptomics
  • Engineering and technology
    • Biomedical image processing
    • Molecular and cellular biomechanics
    • Genetically modified animals
cardiomyopathy thoracic aortic aneurysm and dissection rare diseases pathophysiology animal models Preclinical research
Project description
This research project focuses on investigating the pathophysiology of cardiovascular disease (progression) in Marfan syndrome. Mouse models carrying different genotypes (variants in the fibrillin-1 gene) and presenting with a range of cardiovascular phenotypes, in line with te clinical presentation of Marfan syndrome, are used to study the mechanisms leading to thoracic aortic aneurysm and dissection, as well as cardiomyopathy.