European Training Network to Diagnose: Understand and Treat Stargardt Disease, a Frequent Inherited Blinding Disorder - StarT

01 October 2018 → 31 March 2023
European funding: framework programme
Research disciplines
  • Medical and health sciences
    • Ophtalmology
Stargardt disease
Project description

The ATP-binding cassette transporter gene (ABCA4) is the causal gene for Stargardt disease (STGD1), an inherited blinding disorder that affects an estimated 925 000 people worldwide. ABCA4 mutations are the most common cause of inherited retinal diseases leading to severe visual impairment and blindness. Funded by the Marie Skłodowska-Curie Actions programme, the StarT project is creating an interdisciplinary research training network focusing on all aspects of STGD1 to develop novel treatments. The early stage researchers in training will uncover the regulation of the ABCA4 gene and its missing heritability using innovative approaches, including functional genomics and transcriptomics, bioinformatics, genome editing, stem cells and animal disease models. The aim is to apply this knowledge to the design of new therapies.