Project

The in vivo study of signaling pathways involved in cell survival and cell death within the central nervous system

Duration
01 October 2008 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Immunology
    • Medical biochemistry and metabolism
    • Neurosciences
    • Immunology
    • Medical biochemistry and metabolism
    • Neurosciences
    • Immunology
    • Medical biochemistry and metabolism
    • Neurosciences
Keywords
FADD Amyotrophic Lateral Sclerosis EAE Multiple Sclerosis (MS) A20
 
Project description

NF-kB is a transcriptionfactor which plays a central role in inflammation. The A20 protein is an inhibitor of NF-kB through a negative-feedback loop. Furthermore, FADD, which is usually studied for its role in celldeath signalisation, is also known to excert some NF-kB inhibiting properties. By using tissue-specific knock-out mice for A20 and FADD, their role in neurodegeneration will be studied.