Chronic liver disease has become a major health threat worldwide. A dysregulation in immune response and interaction between the gut and the liver, hence alterations in the gut-liver axis, contribute to chronic liver disease. Numerous efforts are being made to characterize and functionally understand immune cell populations in liver disease, and my team specifically contributed to the hepatic monocyte and macrophage pool in this context. Despite these efforts, still little is known about the immunological crosstalk between the gut and the liver at the cellular level. Here, we will further invest in the role of specific immune cell subsets in the gut-liver axis in the context of chronic liver disease. For this, we will use human samples, mouse models and in vitro assays.