Research Explorer

Project

The role of prolyl hydroxylases in lung epithelial cells and asthma pathogenesis

Code
3E016712
Duration
01 October 2012 → 30 September 2015
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Respiratory medicine
    • Immunology
    • Respiratory medicine
    • Immunology
    • Respiratory medicine
Keywords
lung epithelial cells dendritic cells inflammation asthma
 
Project description
 

In allergic asthma, lung epithelial cells are crucial for the activation of dendritic cells that drives inflammation. During allergen-induced asthma tissue edema can occur, resulting in hypoxia or a low oxygen tension. Prolyl hydroxylases are sensors for hypoxia. In this project, we investigate how overexpression or downregulation of prolyl hydroxylase levels in lung epithelial cells influences house dust mite-induced asthma.