Research Explorer

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Project

Translational research on the role of the Hedgehog pathway, ADAM19 and HTR4 in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)

Outputs and Outcomes

Code

3G031611

Duration

01 January 2011 → 31 December 2014

Funding

Research Foundation - Flanders (FWO)

Promotor

Guy Brusselle

Research disciplines

Medical and health sciences
- Respiratory medicine
- Respiratory medicine
- Respiratory medicine

Keywords

ADAM19 COPD HTR4 Hedgehog pathway

Project description

In a Genome Wide Association (GWA) study we identified SNPs that are significantly associated with lung function in the genes encoding Hedgehog Interacting Protein (HHIP), A Disintegrin and Metallopeptidase domain 19 (ADAM19) and 5-hydroxytryptamine receptor receptor 4 (HTR4). We will study the expression and function of these genes in a mouse model of COPD and in patients with COPD.

English

Dutch

English

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