Code
3G031611
Duration
01 January 2011 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Medical and health sciences
- Respiratory medicine
- Respiratory medicine
- Respiratory medicine
Keywords
ADAM19
COPD
HTR4
Hedgehog pathway
Project description
In a Genome Wide Association (GWA) study we identified SNPs that are significantly associated with lung function in the genes encoding Hedgehog Interacting Protein (HHIP), A Disintegrin and Metallopeptidase domain 19 (ADAM19) and 5-hydroxytryptamine receptor receptor 4 (HTR4). We will study the expression and function of these genes in a mouse model of COPD and in patients with COPD.