Research Explorer

Project

Long-range genetic defects in human developmental disorders.
Code
31518209
Duration
01 January 2009 → 30 December 2011
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
Keywords
transcriptional regulation long-range genetic defect development disorders
 
Project description
 

Long-range regulatory defects can lead to altered gene expression and disease as a result of the dissociation of a gene and its cis-regulatory sequences. Through identification of long-range genetic rearrangements in several human transcription factor-related conditions and the search for cis-elements of their corresponding disease genes, we aim at a better insight in the contribution of long-range genetic defects in the molecular pathogenesis of genetic disorders.