Research Explorer

Project

Aspects of porcine arterivirus entry in macrophages leading to virus persistence
Code
01P05905
Duration
01 January 2008 → 01 October 2008
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
Keywords
macrophages persistence virus
 
Project description
 

We want to investigate how entry of porcine arterivirus in macrophages via the macrophage-specific receptor sialoadhesin results in intracellular virus survival and virus persistence at cellular and animal level. An in vitro model will be set up to investigate how long virus remains infectious after sialoadhesin-dependent internatization in the macrophage.