Inflammation is our body's immediate defense response as protection against injury or infection. Chronic inflammation can lead to serious diseases such as inflammatory bowel disease, asthma, multiple sclerosis and cancer. Through a multidisciplinary approach, we aim to unravel the molecular and cellular mechanisms that drive the development and progression of inflammatory diseases, immunodeficiency or cancer. More specifically, we aim to understand the signaling mechanisms that drive proinflammatory gene expression in immune cells and epithelial barrier cells, initiated by various stimuli such as cytokines and microbes, as well as pathogenic mutations in specific signaling proteins. Whenever possible, we strive to translate basic research into new diagnostics and more effective therapies for patients.