Research Explorer

Project

The gut-renal axis: link between plasma levels of intestinally generated uraemic toxins and gut microbiome profiles in consecutive stages of chronic kidney disease (CKD).
Acronym
CNF
Code
3G017815
Duration
01 January 2015 → 31 December 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Urology and nephrology
    • Laboratory medicine
    • Urology and nephrology
    • Laboratory medicine
    • Microbiology
    • Urology and nephrology
Keywords
uraemic toxins intestinal microbiome Chronic kidney disease
 
Project description
 

The project envisages to link the composition and stability of the intestinal microbiome in CKD patients to plasma levels of intestinally generated protein-bound uraemic toxins through a series of comparative analyses at different stage of CKD. It will reveal measures to alter the intestinal generation, lowering circulating levels, aiming at decreasing cardiovascular morbidity and mortality in CKD patients.