Asymmetry is an important organizational principle in nature and biology. Humans and animals show striking asymmetries in both anatomy and behavior and with our research we aim to contribute to a better understanding of asymmetry in the brain-behavior relationship. In addition to describing the structural and functional differences between both hemispheres, we also focus on the origin, development, and consequences of these differences both in neurotypical individuals (and their different phenotypes) and in exceptional and clinical populations associated with atypical traits or lateralizations. For this we use both behavioral research (neuropsychological tests, questionnaires, observations) and imaging research (magnetic resonance imaging, transcranial Doppler ultrasonography, etc.). We also focus on translational added value by converting the insights gained into practical and clinical recommendations and test development.