Project

New directions for 5-HT4 receptor agonists

Code

179P4508

Duration

01 December 2007 → 01 December 2010

Funding

Private funding via IWT/VLAIO

Promotor

Romain Lefebvre

Research disciplines

Social sciences
- Biological and physiological psychology
- Cognitive science and intelligent systems
- Developmental psychology and ageing
Medical and health sciences
- Gastro-enterology and hepatology
- Neurosciences
- Gastro-enterology and hepatology
- Neurosciences
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Gastro-enterology and hepatology
- Neurosciences

Keywords

5-HT4 receptor heart brain intestine

Project description

The influence of selective 5-HT4 receptor agonists on acetylcholine release from brain slices is examined for possible application in degenerative brain diseases, characterized by memory loss. Parallelly, the influence of the agonists is investigated on peripheral 5-HT4 receptors in the gastro-intestinal tract and in the heart to select the substances with as little peripheral effect as possible.