Project

Multiple myeloma tumor microenvironment characterization in relation to its response to glucocorticoid therapy: from biomarkers to an improved therapy

Code

365S3412

Duration

01 July 2012 → 30 June 2016

Funding

Funding by bilateral agreement (private and foundations)

Promotor

Karolien De Bosscher

Research disciplines

Natural sciences
- Biochemistry and metabolism
- Systems biology
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism

Keywords

glucocorticoid receptor selective glucocorticoid receptor modulation glucocorticoid resistance multiple myeloma

Project description

Glucocorticoids are a cornerstone in the treatment of multiple myeloma, a plasma cell malignancy located in the bone marrow. Prolonged treatment with glucocorticoids leads to GC resistance. We aim to establish novel mechanistic insights in GC resistance development by studying the link between the onset of GC resistance and a dysfunctional GR signaling pathway.