Project

Multiple myeloma tumor microenvironment characterization in relation to its response to glucocorticoid therapy: from biomarkers to an improved therapy

Code
365S3412
Looptijd
01-07-2012 → 30-06-2016
Financiering
Funding by bilateral agreement (private and foundations)
Onderzoeksdisciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Trefwoorden
selectieve glucocorticoid receptor modulatie multipel myeloom Glucocorticoïd receptor glucocorticoïd resistentie
 
Projectomschrijving

Glucocorticoids are a cornerstone in the treatment of multiple myeloma, a plasma cell malignancy located in the bone marrow. Prolonged treatment with glucocorticoids leads to GC resistance. We aim to establish novel mechanistic insights in GC resistance development by studying the link between the onset of GC resistance and a dysfunctional GR signaling pathway.