Code
365S3412
Duration
01 July 2012 → 30 June 2016
Funding
Funding by bilateral agreement (private and foundations)
Promotor
Research disciplines
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Natural sciences
- Biochemistry and metabolism
- Systems biology
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Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
Keywords
glucocorticoid receptor
selective glucocorticoid receptor modulation
glucocorticoid resistance
multiple myeloma
Project description
Glucocorticoids are a cornerstone in the treatment of multiple myeloma, a plasma cell malignancy located in the bone marrow. Prolonged treatment with glucocorticoids leads to GC resistance. We aim to establish novel mechanistic insights in GC resistance development by studying the link between the onset of GC resistance and a dysfunctional GR signaling pathway.