This proposal aims to implement an upgraded multi-axis loading platform integrated with UGCT’s advanced X-ray CT scanners, enabling real-time 4D imaging of materials interactions under realistic conditions. The system allows vertical, lateral, and cyclic loading in saturated and dry environments, supporting research on degradation and performance of steel, concrete, wood, and composite materials, as well as soil processes and root–soil interaction. It will be intensively used by multiple UGent research groups in geotechnics, structural engineering, materials science, soil science, and plant biomechanics. The infrastructure offers unique capabilities for visualizing internal deformation, damage evolution, and mechanical-chemical coupling. It will be the first of its kind in Belgium and among the few in Europe, positioning UGent as a central hub for interdisciplinary research and international collaboration through open-access networks such as EXCITE.