Research Explorer

Project

Investigation of the in vivo role of RIPK1 and RIPK3 in tissue development, homeostasis and inflammation
Code
3G0C3114
Duration
01 January 2014 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Dermatology
    • Gastro-enterology and hepatology
    • Morphological sciences
    • Dermatology
    • Gastro-enterology and hepatology
    • Morphological sciences
    • Dermatology
    • Gastro-enterology and hepatology
    • Morphological sciences
Keywords
skin RIP kinases necrotic cell death Inflammation gut
 
Project description

During recent years it was shown that necrotic cell death is mainly regulated by two kinases, RIPK1 and RIPK3, that control necrotic cell death and can participate in tissue inflammation. The aim of this project is to unravel the physiological and pathological role of RIPK1 and RIPK1 in homeostatic and inflammatory conditions.