Project

Synthesis and biological evaluation of new beta-lactam containing inhibitors of penicillin-binding proteins from resistant bacteria.

Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
Keywords
antibiotics chemical synthesis resistant bacteria beta-lactams virtual screening biological evaluation
 
Project description

To identify novel potential antibiotics, the PBP’s catalyzing the peptidoglycan biosynthesis are targeted, especially the transpeptidase function. Strategies for the inhibitor discovery involve computational techniques, chemical synthesis of potential inhibitors and their structural, biochemical, antimicrobial and toxicological evaluation. This will involve a collaboration with the universities of Ljubljana and Liège.