Caspase-14, a protease, expresion and regulation is associated with epidermal cornification. We study the role of caspase-14 in a number of important epidermal functions and diseases (barrier, anti-microbial activity, psoriasis, etc.). RIP4, a Ser/Thr kinase, exerts an important function in epidermal differentiation and NF-kB activation. We study the molecular signaling pathways involving RIP4.
- The epidermis has evolved to provide a physical and permeability barrier, which is essential for survival. The epidermis provides a unique system to study the cellular mechanisms controlling keratinocyte differentiation and tissue homeostasis. We will study: 1) the role of RIP kinases (RIPK1 and 4) in the skin; 2) the role of A20 (TNFAIP3) in skin diseases.