Research Explorer

Project

Search for new and analysis of known HIV restriction factors
Code
3E009607
Duration
01 October 2007 → 16 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Medical biochemistry and metabolism
    • Immunology
    • Medical biochemistry and metabolism
    • Microbiology
    • Immunology
    • Medical biochemistry and metabolism
Keywords
MAPPIT HIV protein interaction
 
Project description

In the scope of this study we will examine interactions between human proteins of the HIV virus. We will identify new interactions between HIV restriction factors. We will study the interaction between Vif (viron infectivity factor) and Apobec3B (Apolipoprotein B mRNA-editing enzyme-catalytic polyprotein-like 3G) and examine the role of Trim5a and ISG15 (interferon-stimulated gene 15) in HIV restriction.