Project

The structural biology of Interleukin-34, a novel cytokine-ligand for the colony stimulating factor 1 receptor (CSF1R)

Code

01D42310

Duration

01 October 2010 → 30 September 2012

Funding

Regional and community funding: Special Research Fund

Promotor

Savvas Savvides

Fellow

Jan Félix

Research disciplines

Natural sciences
- Medicinal and biomolecular chemistry
- Biochemistry and metabolism
- Molecular and cell biology
- Plant biology
- Systems biology
Medical and health sciences
- Biophysics
- Medical biochemistry and metabolism
- Molecular and cell biology
- Biophysics
- Medical biochemistry and metabolism
- Molecular and cell biology
- Biophysics
- Medical biochemistry and metabolism
- Molecular and cell biology

Keywords

IL34-CSF1R interaction IL34

Project description

We propose an interdisciplinary research project at the frontline of molecular structural biology to dissect the interaction of a novel cytokine, Interleukin-34; with its hematopoietic RTKIII receptor, Colony Stimulating Factor-1 Receptor. The proposed research project aims to elucidate the structural, kinetic and thermodynamic determinants that dictate this unusual cytokine-receptor specificity, using both experimental and computational methods in structural biology.