Project

Identification and validation of molecular mechanisms involved in necrotic cell death

Acronym
3E 021710
Duration
01 October 2010 → 30 August 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Systems biology
Keywords
cell death TNF necroptosis necrosis
 
Project description

We aim to further dissect regulated necrosis, by means of high trouhgpu 5HT) and heigh content screening (HTS) using automated microscopy. The identified mechanism will eventually be validated by in vivo disease model systems in which necrotic ceel death mechanisms is presumed to play a major role (TNF-induces shick, inflammatory bowel disease, diabetes, ischemia/reperfusion).