Project

Biogeography of plethodontid salamanders reflects origin and evolution of antimicrobial skin defenses against lethal chytridiomycosis

Code
01P13013
Duration
01 October 2013 → 30 September 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Microbiology
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Microbiology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural and food sciences
Keywords
amphibia skin secretions resistance antimicrobial peptides Batrachochytrium dendrobatidis chytridiomycosis
 
Project description

This research focusses on how antimicrobial peptides (AMP) in skin secretions of plethodontid salamanders cause resistance for chytridiomycosis and how these peptides have evolved. Consequently the AMP arsenal in 3 plethodontid model species will be explored as well as, the mode of action of potent AMP’s at cellular level and the distribution of genes encoding for potent AMP’s.