Project

Identification of primary target genes of the canonical Wnt pathway and assessment of their clinical relevance to cancer

Duration
01 January 2007 → 31 December 2010
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
cancer embryonic development oncogenes
 
Project description

We want to identify novel target genes of the canonical Wnt pathway, which is often aberrantly activated in human cancer. These genes will be identified in different organs of transgeneic tadpoles (Xenopus) in which the Wnt pathway is genetically manipulated. We will then screen whether these genes are also enriched in human tumor samples with an activated Wnt pathway.