Project

Generation and detailed analysis of novel tools to study the importance of dimerization of the Glucocorticoid Receptor in inflammation.

Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
    • Other biological sciences
  • Medical and health sciences
    • Immunology
    • Molecular and cell biology
    • Immunology
    • Immunology
    • Molecular and cell biology
Keywords
TNF enhancers Glucocorticoid Receptor (GR) Transcription factors Systemic Inflammatory Response Syndrome dimerization
 
Project description

Novel tools to study the importance of dimerization of the GR wil be generated and investigated. Cells and mice will be generated with inducible GR dimerization and these will be used to study the role of GR dimerization in the control of SIRS.