Colorectal cancer (CRC) stands among the most prevalent global cancers, still lacking a definitive cure for its malignant form. Recent research has highlighted the high degree of plasticity in CRC, contributing to malignant progression and therapy resistance. There is evidence indicating the presence of epithelial-to-mesenchymal transition in certain CRC metaplastic subtypes. The expression of ZEB1 and ZEB2, transcription factors associated with epithelial-to-mesenchymal transition (EMT), in intestinal epithelial cells leads to rapid CRC formation. These CRC tumor lesions exhibit graded epithelial dedifferentiation, heightened stemness capacity, distinct metabolic reprogramming, and potential variations in sensitivity to cell death among the plastic cells. This fundamental cancer research project aims to unravel the underlying mechanisms behind these ZEB-driven plasticity changes.