Research Explorer

Project

The role of dopamine D4 receptor ubiquitination and functional differences between the polymorphic variants.
Code
01D31409
Duration
01 October 2009 → 01 October 2011
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Neurosciences
    • Medical biochemistry and metabolism
    • Neurosciences
    • Medical biochemistry and metabolism
    • Neurosciences
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
GPCR dopamine ubiquitin
 
Project description

The dopamine D4 receptor is a G protein- coupled receptor. We have shown that this receptor is ubiquitination upon interaction with KLHL12 (a Kelch-BTB protein) and in this project we will investigate what the functional role of this receptor ubiquitination is.