Research Explorer

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Project

Investigating the effects of regulatory phosphorylation and linear ubiquitination on Pyrin-mediated auto-inflammatory disorders.

Outputs and Outcomes

Publications

Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes

Hannah StocksElisabeth De LeeuwBart LambrechtLinos VandekerckhoveGeert van LooAndy Wullaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Regulation of inflammasome signaling by the linear deubiquitinase OTULIN

Maria Giulia DoglioAndy WullaertGeert van Loo

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van LooAndy Wullaert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion

Maria Giulia DoglioLien VerboomEmily Ruilova SosorangaUlrika FrisingTomoko AsaokaYannick GansemansFilip Van NieuwerburghGeert van LooAndy Wullaert

A1 Journal Article in SCIENCE IMMUNOLOGY

Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection

Elien EeckhoutLisa HamerlinckVeronique JonckheerePetra Van DammeGeert van LooAndy Wullaert

A1 Journal Article in CELL DEATH & DISEASE

Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice

Ulrika FrisingSilvia Ribó GenéMaria Giulia DoglioBernard MalissenGeert van LooAndy Wullaert

A1 Journal Article in EMBO REPORTS