The EU’s plan for a green transition (reducing net greenhouse gas emissions and making Europe carbon-neutral by 2050) hinges on the success of bloc-wide efforts to combat climate change. It is also important for industrial districts throughout Europe to transform into circular economies focussed on sustainability, reduced emissions and consumption. In this context, the EU-funded SYSCHEMIQ project aims to support this transition by providing stakeholders with a demonstration of methodologies that can assist in transitioning to a circular economy that focuses on plastic recycling and reduced waste. To achieve this, SYSCHEMIQ will enable a demonstration of these methodologies in the industrial, cross-border district between the Netherlands, Belgium and Germany.