New strategies of soluble guanylyl cyclase (sGC) activation and their potential role in the treatment of cardiovascular diseases and erectile dysfunction

01 October 2011 → 30 September 2014
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Cardiac and vascular medicine
    • Cardiac and vascular medicine
    • Cardiac and vascular medicine
blood vessels animal research erection nitrogen oxide carbon monoxide soluble guanlylyl cyclase
Project description

sGC is a cardinal enzyme in the maintenance of blood pressure and for eliciting erection. NO released from endothelial cells and NANC neurons is the main activator. Recently designed drugs that directly stimulate sGC independent of NO or that stimulate sGC through generation of CO are of potential clinical interest. The project aims ro discover the basic mechanism of action of these drugs.