Research Explorer

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Project

A novel role for the IRE1/XBP1 branch in dendritic cells: a signaling cascade matures

Outputs and Outcomes

Code

01D29217

Duration

01 October 2017 → 30 September 2018

Funding

Regional and community funding: Special Research Fund

Promotor

Sophie Janssens

Fellow

Victor Bosteels

Research disciplines

Medical and health sciences
- Molecular and cell biology not elsewhere classified

Keywords

crosspresentation dendritic cells

Project description

My lab discovered that the IRE1/XBP1-branch of the unfolded protein response (UPR) is constitutively activated in a specific subset of dendritic cells (DCs). A subsequent RNASeq study revealed a novel role for regulated IRE1 dependent decay (RIDD). In this project, we want to elucidate the physiological role for RIDD and its regulation mechanism during tolerogenic antigen presentation in DCs.

English

Dutch

English

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