Parental Burnout (PB) is a condition characterized by intense exhaustion related to one’s parental role, emotional distancing from one’s children, and a sense of parental ineffectiveness, as a response to chronic and overwhelming parental stress. Despite the growing interest for PB in parents of children with neurotypical development, almost no research investigates feelings of PB in parents of children with special needs, such as Autism Spectrum Disorder (ASD) or Cerebral Palsy (CP). Given that these parents encounter increased pressures and specific challenges in parenting, these parents are likely at elevated risk for PB. This project aims to evaluate to what extent these parents experience PB and to examine the parent, context and child factors and temporal dynamics that tip these vulnerable parents ‘over the edge’ of PB. By adopting a multi-method, multi-informant approach - focusing on both mothers, fathers, and couples - this project addresses four research objectives: (1) to describe PB in and across parents of children with ASD, CP, and a reference group, (2) to identify the antecedents of PB, (3) to explore the dynamic interplay of these antecedents and parental stress in the prediction of PB and (4) to examine the complex between-partner processes in parents of children with ASD or CP. The results of this project will improve the understanding of PB in these parents and pave the paths towards early detection and more tailored parent support.