Research Explorer

Project

Study of the molecular mechanisms by which chronic intestinal inflammation affects stem cell function leading to epithelial inflammation and cancer development
Code
3E000311
Duration
01 October 2011 → 30 September 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Immunology
    • Gastro-enterology and hepatology
    • Immunology
    • Gastro-enterology and hepatology
    • Immunology
Keywords
cancer NF-kB stem cell intestine inflammation
 
Project description
 

Chronic inflammation contributes to tumor promotion and progression, and many of the tumor-promoting effects of inflammation depend on the activation of the transcription factor NF-κB. Interference with NF-κB signalling therefore represents a potential new therapeutic approach. Our project concerns the study of how NF-kB-dependent inflammation affects intestinal tissue physiology and can contribute to the development of intestinal cancer.