Next generation of Light Stabilized Dynamic Materials by shining the light on well-defined polymers

01 October 2020 → Ongoing
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Chemical characterisation of materials
    • Synthesis of materials
    • Macromolecular and materials chemistry not elsewhere classified
Light-Stabilized Dynamic Materials (LSDMs) Darkness-triggered nanoparticle-based drug delivery Well-defined polymers
Project description

The research proposal aims to unravel the potential of the pioneering concept of light-stabilised dynamic materials (LSDMs) by on the one hand introducing controlled radical polymerization to design a variety of functional materials and on the other hand introducing the obtained LSDMs into the field of drug delivery. To achieve high control over these systems, the LSDM concept will be explored by expanding the type of polymer backbones with controlled molecular weights, low dispersity and designed composition and architecture. Guided by the preliminary proof-of-principle, we will aim to precisely finetune the visible light-driven triazolinedione (TAD)-naphthalene LSDM chemistry platform, by investigating the effect of naphthalene substitution on these polymer scaffolds. A range of different state-of-the-art analytical tools will be employed to determine the quality of the generated systems. A library of the new scaffolds and LSDMs will be created in order to provide an insight into the optimum conditions upon which the LSDM strategies are fully exploited. Ultimately, the implementation of the examined LSDMs into drug delivery will be evaluated and encapsulation/release studies of active cargos will be conducted. This research proposal will hence unlock the unique light-switchable dynamic behaviour of our LSDMs into the field of bio-applications, whereby drugs can be delivered by the most benign trigger of all: darkness.